منابع مشابه
Prediction of Salmonella mutagenicity.
The ability of a number of prediction systems was examined to determine how well they could predict Salmonella mutagenicity. The prediction systems included two computer-based systems (CASE and TOPKAT), the measurement of a physiochemical parameter (ke) and the use of structural alerts by an expert chemist. The computer-based systems operators and the chemist were supplied with the structures o...
متن کاملMutagenicity of oxaspiro compounds with Salmonella.
The spiro attachment of an epoxide group to a tetrahydropyran ring in the trichothecene mycotoxins has prompted this study of the mutagenicity and alkylation rates of the trichothecene, anguidine, and 5 related model oxaspiro compounds. While the model compounds were weak alkylating agents of 4-(4-nitrobenzyl)pyridine as a test nucleophile, anguidine lacks such activity. Also, while mutagenicit...
متن کاملMutagenicity of Carcinogenic Mycotoxins in Salmonella typhimuriumi
Fifteen mycotoxins and two chemically modified toxins were tested for mutagenic ability in the His revenant assay with the use of Salmonella typhimurium TA 98 and TA 100. Bisfuranoid mycotoxins such as aflatoxin B,, aflatoxin G,, sterigmatocystin, and O-acetylsterigmatocystin were positive in the routine test method, and epoxide mycotoxins such as PR-toxin and crotocin were positive only when t...
متن کاملMutagenicity of aromatic glycidyl ethers with Salmonella.
6 aromatic glycidyl ethers containing naphthyl, biphenyl or benzylphenyl substituents were synthesized. These epoxides together with the commercially available compounds 2-biphenylyl glycidyl ether were examined for dose-mutagenicity relationships using the plate incorporation Ames test with Salmonella typhimurium strains TA100 and TA1535. Structure-mutagenicity relationships were further exami...
متن کاملThe Ames Salmonella/microsome mutagenicity assay.
The Ames Salmonella/microsome mutagenicity assay (Salmonella test; Ames test) is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances that can produce genetic damage that leads to gene mutations. The test employs several histidine dependent Salmonella strains each carrying different mutations in various genes in the histidine operon. ...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 1996
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/11.5.471